As a consequence, differentiated cells develop a stable and unique DNA methylation pattern that regulates tissue-specific gene. DNA methylation represents a primary epigenetic mark used by cells to regulate which genes are turned on or off. DNA methylation represents an annotation system for marking the genetic text, thus providing instruction as to how and when to read. The impact of DNA methylation on transcription is greater when it is in the transcription unit, and it is primarily a local effect.

General Overview

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Key Points

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